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Clinical Medicine
Scientific Show Stopper
0 Articles
238 Posts
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Germinal center control
The ability of the immune system to fend off specific pathogens following immunization depends the generation high-affinity antibody producing plasma cells (PCs) and long-lived memory B cells....
Published November 8, 2013
Scientific Show Stopper
Initial interactions
One of the leading causes of hospital-acquired infection in immune compromised patients is the fungus, Candida albicans. Â Among patients, both the risk of developing candidiasis and the...
Published November 1, 2013
Scientific Show Stopper
AMP[K]-lifying view of the diabetic kidney
The presence of increased glucose levels in diabetes patients is considered to drive diabetes-associated complications, including retinopathy, neuropathy, and nephropathy. Cultured cells...
Published October 25, 2013
Scientific Show Stopper
Scratching the itch
Chronic itchiness is a symptom of many different skin diseases. The development of the itch sensation is triggered by sensory neurons and this signal is then transferred to the brain. G-coupled...
Published October 15, 2013
Scientific Show Stopper
Nerves in the gut
Hirschprung disease is the result of incomplete development of the enteric nervous system (ENS) within the bowel. The ENS is originates from enteric neural crest–derived cells, which proliferate...
Published October 15, 2013
Scientific Show Stopper
A pain in the back
Pain in the lower back can be caused by a variety of factors including overuse injury, aging, and arthritis. A major source of back pain is lumbar disc degeneration (LDD), which is characterized by...
Published October 8, 2013
Scientific Show Stopper
Wasting Away
Skeletal muscle wasting (cachexia) is a debilitating condition seen in patients with a variety of diseases including cancer. Most research on the underlying mechanisms of cachexia progression...
Published October 1, 2013
Scientific Show Stopper
Changing affinities
The loss of functional primary cilia is associated with many debilitating diseases including the blinding disease Leber congential amaurosis (LCA) and Joubert syndrome, which is the result of...
Published September 24, 2013
Scientific Show Stopper
Shot through the heart (cell membrane)
Reintroduction of oxygenated blood into the heart following an ischemic event induces inflammation that results in cardiomyocyte (CM) death. Integrins are transmembrane receptors that are part...
Published September 16, 2013
Scientific Show Stopper
A clear field of view
One of the leading causes of vision loss is age-related macular degeneration associated with formation of new retinal blood vessels. Current treatments for this condition involve use of...
Published September 9, 2013
Scientific Show Stopper
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