The genetics of Kawasaki disease
Y Onouchi - International journal of rheumatic diseases, 2018 - Wiley Online Library
Y Onouchi
International journal of rheumatic diseases, 2018•Wiley Online LibraryKawasaki disease (KD) is a complex disorder which affects genetically susceptible infants
and children. Several susceptibility genes (eg, ITPKC, CASP 3, CD 40 and ORAI) and
chromosomal regions have been identified through genome‐wide association and genome‐
wide linkage studies to have association with KD. Knowledge of susceptibility genes
involved in the pathogenesis of KD may provide new insights into diagnosis and treatment of
this condition. However, there is much that we still do not know about the genetic basis of …
and children. Several susceptibility genes (eg, ITPKC, CASP 3, CD 40 and ORAI) and
chromosomal regions have been identified through genome‐wide association and genome‐
wide linkage studies to have association with KD. Knowledge of susceptibility genes
involved in the pathogenesis of KD may provide new insights into diagnosis and treatment of
this condition. However, there is much that we still do not know about the genetic basis of …
Abstract
Kawasaki disease (KD) is a complex disorder which affects genetically susceptible infants and children. Several susceptibility genes (e.g., ITPKC, CASP3, CD40 and ORAI) and chromosomal regions have been identified through genome‐wide association and genome‐wide linkage studies to have association with KD. Knowledge of susceptibility genes involved in the pathogenesis of KD may provide new insights into diagnosis and treatment of this condition. However, there is much that we still do not know about the genetic basis of KD.
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