P53 supports endothelial barrier function via APE1/Ref1 suppression

MA Uddin, MS Akhter, A Siejka, JD Catravas… - Immunobiology, 2019 - Elsevier
The tumor suppressor protein P53 is strongly involved in orchestrating cellular defenses in
the diverse variety of human tissues. Anomalies to lung endothelium permeability are
streaming severe consequences towards human health, often associated with fatal
outcomes. Ongoing investigations suggest that P53 exerts a prominent strategic role in
crucial signaling cascades, in charge of both the maintenance and defense of pulmonary
endothelium against toxic intruders. The current study employs human and bovine lung …