Cloning and expression of the human interleukin-6 (BSF-2/IFNβ 2) receptor
K Yamasaki, T Taga, Y Hirata, H Yawata, Y Kawanishi… - Science, 1988 - science.org
K Yamasaki, T Taga, Y Hirata, H Yawata, Y Kawanishi, B Seed, T Taniguchi, T Hirano…
Science, 1988•science.orgInterleukin-6 (IL-6/BSF-2/IFNβ 2) is a multifunctional cytokine that regulates the growth and
differentiation of various tissues, and is known particularly for its role in the immune
response and acute phase reactions. A complementary DNA encoding the human IL-6
receptor (IL-6-R) has now been isolated. The IL-6-R consists of 468 amino acids, including a
signal peptide of∼ 19 amino acids and a domain of∼ 90 amino acids that is similar to a
domain in the immunoglobulin (Ig) superfamily. The cytoplasmic domain of∼ 82 amino …
differentiation of various tissues, and is known particularly for its role in the immune
response and acute phase reactions. A complementary DNA encoding the human IL-6
receptor (IL-6-R) has now been isolated. The IL-6-R consists of 468 amino acids, including a
signal peptide of∼ 19 amino acids and a domain of∼ 90 amino acids that is similar to a
domain in the immunoglobulin (Ig) superfamily. The cytoplasmic domain of∼ 82 amino …
Interleukin-6 (IL-6/BSF-2/IFNβ 2) is a multifunctional cytokine that regulates the growth and differentiation of various tissues, and is known particularly for its role in the immune response and acute phase reactions. A complementary DNA encoding the human IL-6 receptor (IL-6-R) has now been isolated. The IL-6-R consists of 468 amino acids, including a signal peptide of ∼19 amino acids and a domain of ∼90 amino acids that is similar to a domain in the immunoglobulin (Ig) superfamily. The cytoplasmic domain of ∼82 amino acids lacks a tyrosine/kinase domain, unlike other growth factor receptors.
AAAS