The association of the kynurenine pathway of tryptophan metabolism with acute brain dysfunction during critical illness
JRA Wilson, A Morandi, TD Girard… - Critical care …, 2012 - journals.lww.com
Objectives: Plasma tryptophan levels are associated with delirium in critically ill patients.
Although tryptophan has been linked to the pathogenesis of other neurocognitive diseases
through metabolism to neurotoxins via the kynurenine pathway, a role for kynurenine
pathway activity in intensive care unit brain dysfunction (delirium and coma) remains
unknown. This study examined the association between kynurenine pathway activity as
determined by plasma kynurenine concentrations and kynurenine/tryptophan ratios and …
Although tryptophan has been linked to the pathogenesis of other neurocognitive diseases
through metabolism to neurotoxins via the kynurenine pathway, a role for kynurenine
pathway activity in intensive care unit brain dysfunction (delirium and coma) remains
unknown. This study examined the association between kynurenine pathway activity as
determined by plasma kynurenine concentrations and kynurenine/tryptophan ratios and …
