Endocytosis, storage, and release of IgE by human platelets: differences in patients with type I allergy and nonatopic subjects
M Klouche, MF Klinger, W Kühnel, D Wilhelm - Journal of allergy and …, 1997 - Elsevier
Platelets of atopic individuals differ in α-granular contents and in the amount of biologically
active mediators released compared with platelets of nonatopic subjects. Because platelets
carry the low-affinity IgE receptor (CD23), they may contribute to long-lasting IgE sensitivity
by serving as a storage pool for IgE. We compared 45 atopic individuals with immediate-type
allergies and 25 nonatopic control subjects with respect to storage and release of IgE by
their platelets. Platelets of atopic individuals were characterized by a 10-fold higher median …
active mediators released compared with platelets of nonatopic subjects. Because platelets
carry the low-affinity IgE receptor (CD23), they may contribute to long-lasting IgE sensitivity
by serving as a storage pool for IgE. We compared 45 atopic individuals with immediate-type
allergies and 25 nonatopic control subjects with respect to storage and release of IgE by
their platelets. Platelets of atopic individuals were characterized by a 10-fold higher median …