The incidence of factor VIII inhibitors in patients with severe hemophilia A
LW Hoyer - Inhibitors to coagulation factors, 1995 - Springer
LW Hoyer
Inhibitors to coagulation factors, 1995•SpringerInhibitor development is a serious complication of hemophilia A treatment. Although studies
of inhibitor prevalence had been published earlier, 1–3 the possibility that there is increased
risk of inhibitor formation with different Factor VIII (F. VIII)-containing products was first raised
when heat-treated concentrates were introduced. However, this concern was quickly
dropped when it was apparent that heat treatment was necessary to inactivate HIV. As a
result, no systematic study during the 1980s directly compared heat treated and non-heat …
of inhibitor prevalence had been published earlier, 1–3 the possibility that there is increased
risk of inhibitor formation with different Factor VIII (F. VIII)-containing products was first raised
when heat-treated concentrates were introduced. However, this concern was quickly
dropped when it was apparent that heat treatment was necessary to inactivate HIV. As a
result, no systematic study during the 1980s directly compared heat treated and non-heat …
Abstract
Inhibitor development is a serious complication of hemophilia A treatment. Although studies of inhibitor prevalence had been published earlier,1–3 the possibility that there is increased risk of inhibitor formation with different Factor VIII (F.VIII)-containing products was first raised when heat-treated concentrates were introduced. However, this concern was quickly dropped when it was apparent that heat treatment was necessary to inactivate HIV. As a result, no systematic study during the 1980s directly compared heat treated and non-heat treated F.VIII concentrates.
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