Podocyte COX-2 exacerbates diabetic nephropathy by increasing podocyte (pro) renin receptor expression
H Cheng, X Fan, GW Moeckel… - Journal of the American …, 2011 - journals.lww.com
Diabetic nephropathy (DN) increases podocyte cyclooxygenase-2 (COX-2) expression, and
COX-2 inhibition reduces proteinuria and glomerular injury in animal models of diabetes. To
investigate the role of podocyte COX-2 in development of diabetic nephropathy, we
employed a streptozotocin model of diabetic mellitus in wild-type and transgenic mice
expressing COX-2 selectively in podocytes. Progressive albuminuria developed only in
diabetic COX-2 transgenic mice despite hyperglycemia, BP, and GFR being similar to those …
COX-2 inhibition reduces proteinuria and glomerular injury in animal models of diabetes. To
investigate the role of podocyte COX-2 in development of diabetic nephropathy, we
employed a streptozotocin model of diabetic mellitus in wild-type and transgenic mice
expressing COX-2 selectively in podocytes. Progressive albuminuria developed only in
diabetic COX-2 transgenic mice despite hyperglycemia, BP, and GFR being similar to those …