BACKGROUND: The association between a robust or depressed antibody response and
clinical severity of SARS remains unknown. OBJECTIVES: To study seroconversion and the
magnitude of IgG responses in a SARS cohort with different disease severities. STUDY
DESIGN AND METHOD: A retrospective analysis of all acute and convalescent-phase sera
collected from a cohort of laboratory-confirmed SARS cases. Anti-SARS-CoV IgG antibody
was detected using indirect immunofluorescence technique and quantified by two-fold serial …