Reactivation of latent tuberculosis in rhesus macaques by coinfection with simian immunodeficiency virus
Journal of medical primatology, 2011•Wiley Online Library
Abstract Background Tuberculosis (TB) and AIDS together present a devastating public
health challenge. Over 3 million deaths every year are attributed to these twin epidemics.
Annually,∼ 11 million people are coinfected with HIV and Mycobacterium tuberculosis
(Mtb). AIDS is thought to alter the spontaneous rate of latent TB reactivation. Methodology
Macaques are excellent models of both TB and AIDS. Therefore, it is conceivable that they
can also be used to model coinfection. Using clinical, pathological, and microbiological data …
health challenge. Over 3 million deaths every year are attributed to these twin epidemics.
Annually,∼ 11 million people are coinfected with HIV and Mycobacterium tuberculosis
(Mtb). AIDS is thought to alter the spontaneous rate of latent TB reactivation. Methodology
Macaques are excellent models of both TB and AIDS. Therefore, it is conceivable that they
can also be used to model coinfection. Using clinical, pathological, and microbiological data …
Abstract
Background Tuberculosis (TB) and AIDS together present a devastating public health challenge. Over 3 million deaths every year are attributed to these twin epidemics. Annually, ∼11 million people are coinfected with HIV and Mycobacterium tuberculosis (Mtb). AIDS is thought to alter the spontaneous rate of latent TB reactivation.
Methodology Macaques are excellent models of both TB and AIDS. Therefore, it is conceivable that they can also be used to model coinfection. Using clinical, pathological, and microbiological data, we addressed whether latent TB infection in rhesus macaques can be reactivated by infection with simian immunodeficiency virus (SIV).
Results A low‐dose aerosol infection of rhesus macaques with Mtb caused latent, asymptomatic TB infection. Infection of macaques exhibiting latent TB with a rhesus‐specific strain of SIV significantly reactivated TB.
Conclusions Rhesus macaques are excellent model of TB/AIDS coinfection and can be used to study the phenomena of TB latency and reactivation.
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