[PDF][PDF] Germinal center B cell dynamics
L Mesin, J Ersching, GD Victora - Immunity, 2016 - cell.com
L Mesin, J Ersching, GD Victora
Immunity, 2016•cell.comGerminal centers (GCs) are the site of antibody diversification and affinity maturation and as
such are vitally important for humoral immunity. The study of GC biology has undergone a
renaissance in the past 10 years, with a succession of findings that have transformed our
understanding of the cellular dynamics of affinity maturation. In this review, we discuss
recent developments in the field, with special emphasis on how GC cellular and clonal
dynamics shape antibody affinity and diversity during the immune response.
such are vitally important for humoral immunity. The study of GC biology has undergone a
renaissance in the past 10 years, with a succession of findings that have transformed our
understanding of the cellular dynamics of affinity maturation. In this review, we discuss
recent developments in the field, with special emphasis on how GC cellular and clonal
dynamics shape antibody affinity and diversity during the immune response.
Germinal centers (GCs) are the site of antibody diversification and affinity maturation and as such are vitally important for humoral immunity. The study of GC biology has undergone a renaissance in the past 10 years, with a succession of findings that have transformed our understanding of the cellular dynamics of affinity maturation. In this review, we discuss recent developments in the field, with special emphasis on how GC cellular and clonal dynamics shape antibody affinity and diversity during the immune response.
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