Caspase-11 gene expression in response to lipopolysaccharide and interferon-γ requires nuclear factor-κB and signal transducer and activator of transcription (STAT) …
R Schauvliege, J Vanrobaeys, P Schotte… - Journal of Biological …, 2002 - ASBMB
Murine caspase-11, together with caspase-1, is essential for the production of IL-1β in
response to lipopolysaccharide (LPS). In most cells, caspase-11 is only expressed upon
induction with pro-inflammatory stimuli. To understand how caspase-11 expression is
transcriptionally regulated, we isolated the caspase-11 gene promoter by genome walking
and investigated the mechanisms regulating caspase-11 gene expression in macrophages
that are treated with LPS and interferon-γ. Transient transfections with caspase-11 promoter …
response to lipopolysaccharide (LPS). In most cells, caspase-11 is only expressed upon
induction with pro-inflammatory stimuli. To understand how caspase-11 expression is
transcriptionally regulated, we isolated the caspase-11 gene promoter by genome walking
and investigated the mechanisms regulating caspase-11 gene expression in macrophages
that are treated with LPS and interferon-γ. Transient transfections with caspase-11 promoter …
