[HTML][HTML] Membrane microdomains and cytoskeleton organization shape and regulate the IL-7 receptor signalosome in human CD4 T-cells
B Tamarit, F Bugault, AH Pillet, V Lavergne… - Journal of Biological …, 2013 - ASBMB
Interleukin (IL)-7 is the main homeostatic regulator of CD4 T-lymphocytes (helper) at both
central and peripheral levels. Upon activation by IL-7, several signaling pathways, mainly
JAK/STAT, PI3K/Akt and MAPK, induce the expression of genes involved in T-cell
differentiation, activation, and proliferation. We have analyzed the early events of CD4 T-cell
activation by IL-7. We have shown that IL-7 in the first few min induces the formation of
cholesterol-enriched membrane microdomains that compartmentalize its activated receptor …
central and peripheral levels. Upon activation by IL-7, several signaling pathways, mainly
JAK/STAT, PI3K/Akt and MAPK, induce the expression of genes involved in T-cell
differentiation, activation, and proliferation. We have analyzed the early events of CD4 T-cell
activation by IL-7. We have shown that IL-7 in the first few min induces the formation of
cholesterol-enriched membrane microdomains that compartmentalize its activated receptor …
