A divergent response of innate regulatory T-cells to sepsis in humans: circulating invariant natural killer T-cells are preserved
DS Heffernan, SF Monaghan, CS Chung, WG Cioffi… - Human immunology, 2014 - Elsevier
Background Sepsis is associated with severe immunosuppression, evidenced by loss and
dysfunction of CD3+ lymphocytes and γδ-TCR+ T-cells. There is limited data addressing
changes in the invariant natural killer T-(iNKT) cell population with sepsis, and whether such
changes correlate with clinical outcomes. Specifically, septic geriatric patients have marked
mortality. How γδ-TCR+ T-cells and iNKT-cells are altered in the settings of sepsis and
advanced age, and how these changes correlate with mortality are unknown. Methods 49 …
dysfunction of CD3+ lymphocytes and γδ-TCR+ T-cells. There is limited data addressing
changes in the invariant natural killer T-(iNKT) cell population with sepsis, and whether such
changes correlate with clinical outcomes. Specifically, septic geriatric patients have marked
mortality. How γδ-TCR+ T-cells and iNKT-cells are altered in the settings of sepsis and
advanced age, and how these changes correlate with mortality are unknown. Methods 49 …
