Neurotoxicity of oxaliplatin and cisplatin for dorsal root ganglion neurons correlates with platinum–DNA binding
LE Ta, L Espeset, J Podratz, AJ Windebank - Neurotoxicology, 2006 - Elsevier
Cisplatin has been in use for 40 years, primarily for treatment of ovarian and testicular
cancer. Oxaliplatin is the only effective treatment for metastatic colorectal cancer.
Neurotoxicity occurs in up to 30% of patients and is dose-limiting for both drugs. The
neuropathy is characterized by selective sensory loss in the extremities. Cisplatin treatment
is associated with high levels of Pt–DNA binding and apoptosis of dorsal root ganglion
(DRG) neurons. In this study, we directly compared the effects of oxaliplatin on DRG in vitro …
cancer. Oxaliplatin is the only effective treatment for metastatic colorectal cancer.
Neurotoxicity occurs in up to 30% of patients and is dose-limiting for both drugs. The
neuropathy is characterized by selective sensory loss in the extremities. Cisplatin treatment
is associated with high levels of Pt–DNA binding and apoptosis of dorsal root ganglion
(DRG) neurons. In this study, we directly compared the effects of oxaliplatin on DRG in vitro …
