The integrity of central and peripheral nervous system myelin is affected in numerous lipid
metabolism disorders. This vulnerability was so far mostly attributed to the extraordinarily
high level of lipid synthesis that is required for the formation of myelin, and to the relative
autonomy in lipid synthesis of myelinating glial cells because of blood barriers shielding the
nervous system from circulating lipids. Recent insights from analysis of inherited lipid
disorders, especially those with prevailing lipid depletion and from mouse models with glia …