Thymic microenvironment reconstitution after postnatal human thymus transplantation
B Li, J Li, BH Devlin, ML Markert - Clinical Immunology, 2011 - Elsevier
A functional thymus develops after cultured thymus tissue is transplanted into subjects with
complete DiGeorge anomaly. To gain insight into how the process occurs, 7 post-
transplantation thymus biopsy tissues were evaluated. In 5 of 7 biopsies, the thymus
appeared to be predominantly cortex with thymocytes expressing cortical markers.
Unexpectedly, the epithelium expressed both cortical [cortical dendritic reticulum antigen 2
(CDR2)] and medullary [cytokeratin (CK) 14] markers. Early medullary development was …
complete DiGeorge anomaly. To gain insight into how the process occurs, 7 post-
transplantation thymus biopsy tissues were evaluated. In 5 of 7 biopsies, the thymus
appeared to be predominantly cortex with thymocytes expressing cortical markers.
Unexpectedly, the epithelium expressed both cortical [cortical dendritic reticulum antigen 2
(CDR2)] and medullary [cytokeratin (CK) 14] markers. Early medullary development was …
