Diuretic-induced hyponatremia and sustained antidiuresis

RE Fuisz, DP Lauler, P Cohen - The American journal of medicine, 1962 - Elsevier
A patient demonstrating acute symptomatic hyponatremia following the administration of
therapeutic doses of chlorothiazide is presented, with appropriate balance data. It is
suggested that this hyponatremia was initiated by both a renal and extrarenal effect and then
maintained via the mediation of a receptor system sensitive to minute changes in
extracellular fluid volume. The effector site of this system was renal and associated with the
release of antidiuretic hormone and water conservation despite marked serum hypotonicity …