Attenuation of the September epidemic of asthma exacerbations in children: a randomized, controlled trial of montelukast added to usual therapy

NW Johnston, PJ Mandhane, J Dai, JM Duncan… - …, 2007 - publications.aap.org
BACKGROUND. A recurring epidemic of asthma exacerbations in children occurs annually
in September in North America when school resumes after summer vacation. OBJECTIVE.
Our goal was to determine whether montelukast, added to usual asthma therapy, would
reduce days with worse asthma symptoms and unscheduled physician visits of children
during the September epidemic. PATIENTS AND METHODS. A total of 194 asthmatic
children aged 2 to 14 years, stratified according to age group (2–5, 6–9, and 10–14 years) …