The dorsomedial hypothalamus and the response to stress: part renaissance, part revolution
JA DiMicco, BC Samuels, MV Zaretskaia… - Pharmacology …, 2002 - Elsevier
Emotional stress provokes a stereotyped pattern of autonomic and endocrine changes that
is highly conserved across diverse mammalian species. Nearly 50 years ago, a specific
region of the hypothalamus, the hypothalamic defense area, was defined by the discovery
that electrical stimulation in this area evoked changes that replicated this pattern. Attention
later shifted to the hypothalamic paraventricular nucleus (PVN) owing to (1) elucidation of its
role as the final common pathway mediating activation of the hypothalamic–pituitary …
is highly conserved across diverse mammalian species. Nearly 50 years ago, a specific
region of the hypothalamus, the hypothalamic defense area, was defined by the discovery
that electrical stimulation in this area evoked changes that replicated this pattern. Attention
later shifted to the hypothalamic paraventricular nucleus (PVN) owing to (1) elucidation of its
role as the final common pathway mediating activation of the hypothalamic–pituitary …