[HTML][HTML] S100A4, a mediator of metastasis

SC Garrett, KM Varney, DJ Weber… - Journal of Biological …, 2006 - ASBMB
The transition from benign tumor growth to malignancy is manifested by the ability of tumor
cells to traverse tissue barriers and invade surrounding tissues. The traversal of basement
membrane barriers is thought to be the critical event in the initiation of the metastatic
cascade and, as described by the three-step hypothesis of metastasis, involves attachment
to the extracellular matrix, local proteolysis, and subsequent migration (1). In recent years, a
number of specific genes have been identified, the expressions of which correlate with …