[PDF][PDF] CaV1. 2 calcium channels: just cut out to be regulated?

RD Groth, NN Tirko, RW Tsien - Neuron, 2014 - cell.com
RD Groth, NN Tirko, RW Tsien
Neuron, 2014cell.com
Tight regulation of calcium entry through the L-type calcium channel Ca V 1.2 ensures
optimal excitation-response coupling. In this issue of Neuron, Michailidis et al.(2014)
demonstrate that Ca V 1.2 activity triggers negative feedback regulation through proteolytic
cleavage of the channel within the core of the pore-forming subunit.
Tight regulation of calcium entry through the L-type calcium channel CaV1.2 ensures optimal excitation-response coupling. In this issue of Neuron, Michailidis et al. (2014) demonstrate that CaV1.2 activity triggers negative feedback regulation through proteolytic cleavage of the channel within the core of the pore-forming subunit.
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