[HTML][HTML] Tumor STAT1 transcription factor activity enhances breast tumor growth and immune suppression mediated by myeloid-derived suppressor cells

LM Hix, J Karavitis, MW Khan, YH Shi… - Journal of Biological …, 2013 - ASBMB
Previous studies had implicated the IFN-γ transcription factor signal transducer and activator
of transcription 1 (STAT1) as a tumor suppressor. However, accumulating evidence has
correlated increased STAT1 activation with increased tumor progression in multiple types of
cancer, including breast cancer. Indeed, we present evidence that tumor up-regulation of
STAT1 activity in human and mouse mammary tumors correlates with increasing disease
progression to invasive carcinoma. A microarray analysis comparing low aggressive TM40D …