The relevance of circadian rhythms and timekeeping for human health has been
increasingly recognized not only by sleep medicine but also by many other medical
specialties. Twenty-four-hour diurnal fluctuations in symptom intensity, responsiveness to
treatment modalities, and survival have been well documented. Important advances in
circadian biology over the past several decades provide an opportunity to systematically
investigate relationships between diseases, endogenous circadian rhythms, and exogenous …