Pyroptosis: host cell death and inflammation

T Bergsbaken, SL Fink, BT Cookson - Nature Reviews Microbiology, 2009 - nature.com
T Bergsbaken, SL Fink, BT Cookson
Nature Reviews Microbiology, 2009nature.com
Eukaryotic cells can initiate several distinct programmes of self-destruction, and the nature of
the cell death process (non-inflammatory or proinflammatory) instructs responses of
neighbouring cells, which in turn dictates important systemic physiological outcomes.
Pyroptosis, or caspase 1-dependent cell death, is inherently inflammatory, is triggered by
various pathological stimuli, such as stroke, heart attack or cancer, and is crucial for
controlling microbial infections. Pathogens have evolved mechanisms to inhibit pyroptosis …
Abstract
Eukaryotic cells can initiate several distinct programmes of self-destruction, and the nature of the cell death process (non-inflammatory or proinflammatory) instructs responses of neighbouring cells, which in turn dictates important systemic physiological outcomes. Pyroptosis, or caspase 1-dependent cell death, is inherently inflammatory, is triggered by various pathological stimuli, such as stroke, heart attack or cancer, and is crucial for controlling microbial infections. Pathogens have evolved mechanisms to inhibit pyroptosis, enhancing their ability to persist and cause disease. Ultimately, there is a competition between host and pathogen to regulate pyroptosis, and the outcome dictates life or death of the host.
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