Differences in airway cytokine profile in severe asthma compared to moderate asthma
J Shannon, P Ernst, Y Yamauchi, R Olivenstein… - Chest, 2008 - Elsevier
Background Some studies of severe asthma suggest that persistence or alteration in the
pattern of inflammation may be associated with the severity of the disease. Whether there
are differences in the expression of the principal cytokines and chemokines relevant to
eosinophilic and neutrophilic inflammation in the airway tissues of severe compared to
moderate asthmatics has not been determined. The aim of this study was to compare the
patterns of expression of representative T-helper (Th) type 1 (interferon [IFN]-γ) and Th-2 …
pattern of inflammation may be associated with the severity of the disease. Whether there
are differences in the expression of the principal cytokines and chemokines relevant to
eosinophilic and neutrophilic inflammation in the airway tissues of severe compared to
moderate asthmatics has not been determined. The aim of this study was to compare the
patterns of expression of representative T-helper (Th) type 1 (interferon [IFN]-γ) and Th-2 …