Gene expression of the GATA-3 transcription factor is increased in atopic asthma
Y Nakamura, O Ghaffar, R Olivenstein, RA Taha… - Journal of Allergy and …, 1999 - Elsevier
Background: High expression of IL-5 by T cells in the airways of asthmatic individuals is
believed to play a fundamental role in the eosinophilia associated with this disease.
Recently, the transcription factor GATA-3 was shown to be critical for IL-5 gene expression in
TH2 cells in vitro. Objective: Our aim was to examine the expression of GATA-3 mRNA and
its colocalization within the airways of asthmatic and nonasthmatic individuals. Methods: We
investigated the association between GATA-3 gene expression, airway inflammatory cells …
believed to play a fundamental role in the eosinophilia associated with this disease.
Recently, the transcription factor GATA-3 was shown to be critical for IL-5 gene expression in
TH2 cells in vitro. Objective: Our aim was to examine the expression of GATA-3 mRNA and
its colocalization within the airways of asthmatic and nonasthmatic individuals. Methods: We
investigated the association between GATA-3 gene expression, airway inflammatory cells …