Distinguishing severe asthma phenotypes: role of age at onset and eosinophilic inflammation
C Miranda, A Busacker, S Balzar, J Trudeau… - Journal of Allergy and …, 2004 - Elsevier
BACKGROUND: Asthma is a heterogeneous process, yet little is understood regarding
phenotypes. OBJECTIVE: To determine whether phenotypic differences exist between early-
onset, severe asthma as compared with late-onset disease and whether the presence or
absence of eosinophilia influences the phenotypes. METHODS: Cross-sectional analysis of
integrated clinical, physiologic, and pathologic data collected from 80 subjects with severe
asthma. Subjects were divided into those with asthma onset before age 12 years (n= 50) …
phenotypes. OBJECTIVE: To determine whether phenotypic differences exist between early-
onset, severe asthma as compared with late-onset disease and whether the presence or
absence of eosinophilia influences the phenotypes. METHODS: Cross-sectional analysis of
integrated clinical, physiologic, and pathologic data collected from 80 subjects with severe
asthma. Subjects were divided into those with asthma onset before age 12 years (n= 50) …