Prostaglandin D2 pathway upregulation: relation to asthma severity, control, and TH2 inflammation
ML Fajt, SL Gelhaus, B Freeman, CE Uvalle… - Journal of allergy and …, 2013 - Elsevier
BACKGROUND: Bronchoalveolar lavage (BAL) fluid prostaglandin D2 (PGD2) levels are
increased in patients with severe, poorly controlled asthma in association with epithelial
mast cells (MCs). PGD2, which is generated by hematopoietic prostaglandin D synthase
(HPGDS), acts on 3 G protein–coupled receptors, including chemoattractant receptor–
homologous molecule expressed on TH2 lymphocytes (CRTH2) and PGD2 receptor 1
(DP1). However, much remains to be understood regarding the presence and activation of …
increased in patients with severe, poorly controlled asthma in association with epithelial
mast cells (MCs). PGD2, which is generated by hematopoietic prostaglandin D synthase
(HPGDS), acts on 3 G protein–coupled receptors, including chemoattractant receptor–
homologous molecule expressed on TH2 lymphocytes (CRTH2) and PGD2 receptor 1
(DP1). However, much remains to be understood regarding the presence and activation of …