Maximal β3-adrenergic regulation of lipolysis involves Src and epidermal growth factor receptor-dependent ERK1/2 activation
J Robidoux, N Kumar, KW Daniel, F Moukdar… - Journal of Biological …, 2006 - ASBMB
Catecholamine-stimulated lipolysis is primarily a β-adrenergic and cAMP-dependent event.
In previous studies we established that the β 3-adrenergic receptor (β 3 AR) in adipocytes
utilizes a unique mechanism to stimulate extracellular signal-regulated kinases 1 and 2
(ERK) by direct recruitment and activation of Src kinase. Therefore, we investigated the role
of the ERK pathway in adipocyte metabolism and found that the β 3 AR agonist CL316, 243
regulates lipolysis through both cAMP-dependent protein kinase (PKA) and ERK. Inhibition …
In previous studies we established that the β 3-adrenergic receptor (β 3 AR) in adipocytes
utilizes a unique mechanism to stimulate extracellular signal-regulated kinases 1 and 2
(ERK) by direct recruitment and activation of Src kinase. Therefore, we investigated the role
of the ERK pathway in adipocyte metabolism and found that the β 3 AR agonist CL316, 243
regulates lipolysis through both cAMP-dependent protein kinase (PKA) and ERK. Inhibition …