Insulin promotes hepatic apolipoprotein B100 (apoB100) degradation, whereas insulin
resistance is a major cause of hepatic apoB100/triglyceride overproduction in type 2
diabetes. The cellular trafficking receptor sortilin 1 (Sort1) was recently identified to transport
apoB100 to the lysosome for degradation in the liver and thus regulate plasma cholesterol
and triglyceride levels. Genetic variation of SORT1 was strongly associated with
cardiovascular disease risk in humans. The major goal of this study is to investigate the …