[HTML][HTML] Glycerol-3-phosphate acyltransferase (GPAT)-1, but not GPAT4, incorporates newly synthesized fatty acids into triacylglycerol and diminishes fatty acid …
AA Wendel, DE Cooper, OR Ilkayeva, DM Muoio… - Journal of Biological …, 2013 - ASBMB
Four glycerol-3-phosphate acyltransferase (GPAT) isoforms, each encoded by a separate
gene, catalyze the initial step in glycerolipid synthesis; in liver, the major isoforms are
GPAT1 and GPAT4. To determine whether each of these hepatic isoforms performs a unique
function in the metabolism of fatty acid, we measured the incorporation of de novo
synthesized fatty acid or exogenous fatty acid into complex lipids in primary mouse
hepatocytes from control, Gpat1−/−, and Gpat4−/− mice. Although hepatocytes from each …
gene, catalyze the initial step in glycerolipid synthesis; in liver, the major isoforms are
GPAT1 and GPAT4. To determine whether each of these hepatic isoforms performs a unique
function in the metabolism of fatty acid, we measured the incorporation of de novo
synthesized fatty acid or exogenous fatty acid into complex lipids in primary mouse
hepatocytes from control, Gpat1−/−, and Gpat4−/− mice. Although hepatocytes from each …
