Role of stearoyl-coenzyme A desaturase in lipid metabolism
M Miyazaki, JM Ntambi - Prostaglandins, Leukotrienes and Essential Fatty …, 2003 - Elsevier
Stearoyl-CoA desaturase (SCD)(EC 1.14. 99.5) is an endoplasmic reticulum-bound enzyme
that catalyzes the Δ9-cis desaturation of saturated fatty acyl-CoAs, the preferred substrates
being palmitoyl-and stearoyl-CoA, which are converted to palmitoleoyl-and oleoyl-CoA,
respectively. These monounsaturated fatty acids are used as substrates for the synthesis of
triglycerides, wax esters, cholesteryl esters and membrane phospholipids. The saturated to
monounsaturated fatty acid ratio affects membrane phospholipid composition and alteration …
that catalyzes the Δ9-cis desaturation of saturated fatty acyl-CoAs, the preferred substrates
being palmitoyl-and stearoyl-CoA, which are converted to palmitoleoyl-and oleoyl-CoA,
respectively. These monounsaturated fatty acids are used as substrates for the synthesis of
triglycerides, wax esters, cholesteryl esters and membrane phospholipids. The saturated to
monounsaturated fatty acid ratio affects membrane phospholipid composition and alteration …
