[HTML][HTML] A novel ankyrin repeat-containing gene (Kank) located at 9p24 is a growth suppressor of renal cell carcinoma
S Sarkar, BC Roy, N Hatano, T Aoyagi, K Gohji… - Journal of Biological …, 2002 - ASBMB
By a combination of genome subtraction and comprehensive analysis of loss of
heterozygosity based on mapping hemizygous deletions for a potential tumor-related locus,
a minimum overlapping region of deletions at 9p24 the size of 165 kb was identified and
found to harbor a new potential tumor suppressor gene for renal cell carcinoma, the Kank
gene. Kank (forkidney ankyrin repeat-containing protein) contains four ankyrin repeats at its
C terminus. Expression of the gene was suppressed in 6 of 8 or 6 of 10 cancer tissues …
heterozygosity based on mapping hemizygous deletions for a potential tumor-related locus,
a minimum overlapping region of deletions at 9p24 the size of 165 kb was identified and
found to harbor a new potential tumor suppressor gene for renal cell carcinoma, the Kank
gene. Kank (forkidney ankyrin repeat-containing protein) contains four ankyrin repeats at its
C terminus. Expression of the gene was suppressed in 6 of 8 or 6 of 10 cancer tissues …