[HTML][HTML] Th17 Cell Accumulation Is Decreased during Chronic Experimental Colitis by (n-3) PUFA in Fat-1 Mice3
JM Monk, Q Jia, E Callaway, B Weeks, RC Alaniz… - The Journal of …, 2012 - Elsevier
During colon inflammation, Th17 cells and immunosuppressive regulatory T cells (Treg) are
thought to play promotive and preventative roles, respectively. Dietary (n-3) PUFA favorably
modulate intestinal inflammation in part by downregulating T-cell activation and functionality.
We used the Fat-1 mouse, a genetic model that synthesizes long-chain (n-3) PUFA de novo,
to test the hypothesis that (n-3) PUFA protect against colonic inflammation by modulating the
polarization of Treg and Th17 cells during colitis. Male and female wild-type (WT) andFat …
thought to play promotive and preventative roles, respectively. Dietary (n-3) PUFA favorably
modulate intestinal inflammation in part by downregulating T-cell activation and functionality.
We used the Fat-1 mouse, a genetic model that synthesizes long-chain (n-3) PUFA de novo,
to test the hypothesis that (n-3) PUFA protect against colonic inflammation by modulating the
polarization of Treg and Th17 cells during colitis. Male and female wild-type (WT) andFat …