The role of oxidative stress in Alzheimer disease

WR Markesbery - Archives of neurology, 1999 - jamanetwork.com
Increasing evidence demonstrates that oxidative stress causes damage to cell function with
aging and is involved in a number of age-related disorders including atherosclerosis, ar-
thritis, and neurodegenerative disorders. In the neurodegenerative diseases, oxidative
stress has been implicated in amyotrophic lateral sclerosis, Parkinson disease, Huntington
disease, and Alzheimer disease (AD). The neurodegenerative disorder receiving the most
attention has been AD, in which an increase occurs in oxidation of brain lipids …