Hyperglycemia and renin-dependent hypertension synergize to model diabetic nephropathy
BR Conway, J Rennie, MA Bailey… - Journal of the …, 2012 - journals.lww.com
Rodent models exhibit only the earliest features of human diabetic nephropathy, which limits
our ability to investigate new therapies. Hypertension is a prerequisite for advanced diabetic
nephropathy in humans, so its rarity in typical rodent models may partly explain their
resistance to nephropathy. Here, we used the Cyp1a1mRen2 rat, in which the murine renin-
2 gene is incorporated under the Cytochrome P4501a1 promoter. In this transgenic strain,
administration of low-dose dietary indole-3-carbinol induces moderate hypertension. In the …
our ability to investigate new therapies. Hypertension is a prerequisite for advanced diabetic
nephropathy in humans, so its rarity in typical rodent models may partly explain their
resistance to nephropathy. Here, we used the Cyp1a1mRen2 rat, in which the murine renin-
2 gene is incorporated under the Cytochrome P4501a1 promoter. In this transgenic strain,
administration of low-dose dietary indole-3-carbinol induces moderate hypertension. In the …