TRPC channel modulation in podocytes—inching toward novel treatments for glomerular disease
S El Hindi, J Reiser - Pediatric Nephrology, 2011 - Springer
S El Hindi, J Reiser
Pediatric Nephrology, 2011•SpringerGlomerular kidney disease is a major healthcare burden and considered to represent a sum
of disorders that evade a refined and effective treatment. Excellent biological and genetic
studies have defined pathways that go awry in podocytes, which are the regulatory cells of
the glomerular filter. The question now is how to define targets for novel improved therapies.
In this review, we summarize critical points around targeting the TRPC6 channel in
podocytes.
of disorders that evade a refined and effective treatment. Excellent biological and genetic
studies have defined pathways that go awry in podocytes, which are the regulatory cells of
the glomerular filter. The question now is how to define targets for novel improved therapies.
In this review, we summarize critical points around targeting the TRPC6 channel in
podocytes.
Abstract
Glomerular kidney disease is a major healthcare burden and considered to represent a sum of disorders that evade a refined and effective treatment. Excellent biological and genetic studies have defined pathways that go awry in podocytes, which are the regulatory cells of the glomerular filter. The question now is how to define targets for novel improved therapies. In this review, we summarize critical points around targeting the TRPC6 channel in podocytes.
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