CKI, there's more than one: casein kinase I family members in Wnt and Hedgehog signaling

MA Price - Genes & development, 2006 - genesdev.cshlp.org
MA Price
Genes & development, 2006genesdev.cshlp.org
Multiple members of the casein kinase I family of serine/threonine protein kinases are
involved in positive and negative roles in Wnt and Hedgehog signaling. Here I review these
roles, including recent results on casein kinase I (CKI) phosphorylation and activation of
LRP6, and CKI phosphorylation of Ci and mediation of Ci–Slimb/β–TrCP binding.
Multiple members of the casein kinase I family of serine/threonine protein kinases are involved in positive and negative roles in Wnt and Hedgehog signaling. Here I review these roles, including recent results on casein kinase I (CKI) phosphorylation and activation of LRP6, and CKI phosphorylation of Ci and mediation of Ci–Slimb/β–TrCP binding.
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