[HTML][HTML] Glycogen synthase kinase-3β inhibitors prevent cellular polyglutamine toxicity caused by the Huntington's disease mutation
J Carmichael, KL Sugars, YP Bao… - Journal of Biological …, 2002 - ASBMB
Huntington's disease is one of nine known neurodegenerative disorders caused by an
expanded polyglutamine (poly (Q)) tract in the disease protein. These diseases are
associated with intraneuronal protein aggregates. Heat-inducible chaperones like HSP70
and HSP27 suppress poly (Q) aggregation and/or toxicity/cell death. Heat shock
transcription factors, including HSF-1, regulate HSP70 and HSP27 expression. HSF-1
activity is reduced by glycogen synthase kinase-3 (GSK-3) and enhanced by GSK-3 …
expanded polyglutamine (poly (Q)) tract in the disease protein. These diseases are
associated with intraneuronal protein aggregates. Heat-inducible chaperones like HSP70
and HSP27 suppress poly (Q) aggregation and/or toxicity/cell death. Heat shock
transcription factors, including HSF-1, regulate HSP70 and HSP27 expression. HSF-1
activity is reduced by glycogen synthase kinase-3 (GSK-3) and enhanced by GSK-3 …