The mammalian target of rapamycin (mTOR) is an evolutionarily conserved serine/threonine
kinase and the founding member of a signaling pathway that regulates many fundamental
features of cell growth and division. In cells, mTOR acts as the catalytic subunit of two
functionally distinct complexes, called mTOR Complex 1 (mTORC1) and mTOR Complex 2
(mTORC2). Together, these complexes coordinate a variety of processes that include
protein translation, autophagy, proliferation, survival and metabolism in response to nutrient …