The eukaryotic cell depends on multitiered homeostatic systems ensuring maintenance of
proteostasis, organellar integrity, function and turnover, and overall cellular viability. At the
two opposite ends of the homeostatic system spectrum are heat shock response and
autophagy. Here, we tested whether there are interactions between these homeostatic
systems, one universally operational in all prokaryotic and eukaryotic cells, and the other
one (autophagy) is limited to eukaryotes. We found that heat shock response regulates …