[HTML][HTML] Dectin-1-triggered recruitment of light chain 3 protein to phagosomes facilitates major histocompatibility complex class II presentation of fungal-derived …
J Ma, C Becker, CA Lowell, DM Underhill - Journal of Biological Chemistry, 2012 - ASBMB
Dectin-1 is a pattern recognition receptor that is important for innate immune responses
against fungi in humans and mice. Dectin-1 binds to β-glucans in fungal cell walls and
triggers phagocytosis, production of reactive oxygen by the NADPH oxidase, and
inflammatory cytokine production which all contribute to host immune responses against
fungi. Although the autophagy pathway was originally characterized for its role in the
formation of double-membrane compartments engulfing cytosolic organelles and debris …
against fungi in humans and mice. Dectin-1 binds to β-glucans in fungal cell walls and
triggers phagocytosis, production of reactive oxygen by the NADPH oxidase, and
inflammatory cytokine production which all contribute to host immune responses against
fungi. Although the autophagy pathway was originally characterized for its role in the
formation of double-membrane compartments engulfing cytosolic organelles and debris …