[HTML][HTML] Lack of cAMP-response element-binding protein 1 in the hypothalamus causes obesity
F Chiappini, LL Cunha, JC Harris… - Journal of biological …, 2011 - ASBMB
The melanocortin system in the hypothalamus controls food intake and energy expenditure.
Its disruption causes severe obesity in mice and humans. cAMP-response element-binding
protein 1 (CREB1) has been postulated to play an important role downstream of the
melanocortin-4 receptor (MC4R), but this hypothesis has never been confirmed in vivo. To
test this, we generated mice that lack CREB1 in SIM1-expressing neurons, of the
paraventricular nucleus (PVN), which are known to be MC4R-positive. Interestingly, CREB1 …
Its disruption causes severe obesity in mice and humans. cAMP-response element-binding
protein 1 (CREB1) has been postulated to play an important role downstream of the
melanocortin-4 receptor (MC4R), but this hypothesis has never been confirmed in vivo. To
test this, we generated mice that lack CREB1 in SIM1-expressing neurons, of the
paraventricular nucleus (PVN), which are known to be MC4R-positive. Interestingly, CREB1 …