[HTML][HTML] Decorin, a novel player in the insulin-like growth factor system
E Schönherr, C Sunderkötter, RV Iozzo… - Journal of Biological …, 2005 - ASBMB
Decorin is a multifunctional proteoglycan that is expressed by sprouting endothelial cells. Its
expression supports capillary formation and cell survival. Previously, it was shown that some
effects of decorin are mediated by protein kinase B and the cyclin-dependent kinase
inhibitor, p21. However, the cell surface receptor responsible for these effects was unknown.
We demonstrate that decorin binds to the insulin-like growth factor-I (IGF-I) receptor on
endothelial cells with an affinity in the nanomolar range (KD= 18 nm), which is comparable …
expression supports capillary formation and cell survival. Previously, it was shown that some
effects of decorin are mediated by protein kinase B and the cyclin-dependent kinase
inhibitor, p21. However, the cell surface receptor responsible for these effects was unknown.
We demonstrate that decorin binds to the insulin-like growth factor-I (IGF-I) receptor on
endothelial cells with an affinity in the nanomolar range (KD= 18 nm), which is comparable …