Vitamin D receptor (VDR)-mediated actions of 1α, 25 (OH) 2vitamin D3: Genomic and non-genomic mechanisms
MR Haussler, PW Jurutka, M Mizwicki… - Best practice & research …, 2011 - Elsevier
The conformationally flexible secosteroid, 1α, 25 (OH) 2vitamin D3 (1α, 25 (OH) 2D3)
initiates biological responses via binding to the vitamin D receptor (VDR). The VDR contains
two overlapping ligand binding sites, a genomic pocket (VDR-GP) and an alternative pocket
(VDR-AP), that respectively bind a bowl-like ligand configuration (gene transcription) or a
planar-like ligand shape (rapid responses). When occupied by 1α, 25 (OH) 2D3, the VDR-
GP interacts with the retinoid X receptor to form a heterodimer that binds to vitamin D …
initiates biological responses via binding to the vitamin D receptor (VDR). The VDR contains
two overlapping ligand binding sites, a genomic pocket (VDR-GP) and an alternative pocket
(VDR-AP), that respectively bind a bowl-like ligand configuration (gene transcription) or a
planar-like ligand shape (rapid responses). When occupied by 1α, 25 (OH) 2D3, the VDR-
GP interacts with the retinoid X receptor to form a heterodimer that binds to vitamin D …