The Sp1 transcription factor gene (SP1) and the 1, 25-dihydroxyvitamin D3 receptor gene (VDR) are colocalized on human chromosome arm 12q and rat chromosome …
J Szpirer, C Szpirer, M Riviere, G Levan, P Marynen… - Genomics, 1991 - Elsevier
J Szpirer, C Szpirer, M Riviere, G Levan, P Marynen, JJ Cassiman, R Wiese, HF DeLuca
Genomics, 1991•ElsevierBy means of somatic cell hybrids segregating either human or rat chromosomes, the genes
encoding the transcription factor Sp1 (SP1) and the 1, 25-dihydroxyvitamin D 3 receptor
(VDR) were both assigned to human chromosome arm 12q and to rat chromosome 7. This
result implies that the locus for the clinical disorder vitamin D dependency rickets type II
maps on 12q. The phenylalanine hydroxylase (PAH) and the retinoic acid receptor-γ
(RARG) genes also map on human chromosome arm 12q and rat chromosome 7, indicating …
encoding the transcription factor Sp1 (SP1) and the 1, 25-dihydroxyvitamin D 3 receptor
(VDR) were both assigned to human chromosome arm 12q and to rat chromosome 7. This
result implies that the locus for the clinical disorder vitamin D dependency rickets type II
maps on 12q. The phenylalanine hydroxylase (PAH) and the retinoic acid receptor-γ
(RARG) genes also map on human chromosome arm 12q and rat chromosome 7, indicating …
Abstract
By means of somatic cell hybrids segregating either human or rat chromosomes, the genes encoding the transcription factor Sp1 (SP1) and the 1,25-dihydroxyvitamin D3 receptor (VDR) were both assigned to human chromosome arm 12q and to rat chromosome 7. This result implies that the locus for the clinical disorder vitamin D dependency rickets type II maps on 12q. The phenylalanine hydroxylase (PAH) and the retinoic acid receptor-γ (RARG) genes also map on human chromosome arm 12q and rat chromosome 7, indicating that a synteny group is conserved on these chromosomes.
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