TRPV-5 Mediates a Receptor Activator of NF-κB (RANK) Ligand-induced Increase in Cytosolic Ca2+ in Human Osteoclasts and Down-regulates Bone Resorption*♦
Most of the signaling effectors located downstream of receptor activator of NF-κB (RANK)
activation are calcium-sensitive. However, the early signaling events that lead to the
mobilization of intracellular calcium in human osteoclasts are still poorly understood. The Ca
2+-sensitive fluorescent probe Fura2 was used to detect changes in the intracellular
concentration of Ca 2+([Ca 2+] i) in a model of human osteoclasts. Stimulating these cells
with receptor activator of NF-κB ligand (RANKL) induced a rapid and significant increase in …
activation are calcium-sensitive. However, the early signaling events that lead to the
mobilization of intracellular calcium in human osteoclasts are still poorly understood. The Ca
2+-sensitive fluorescent probe Fura2 was used to detect changes in the intracellular
concentration of Ca 2+([Ca 2+] i) in a model of human osteoclasts. Stimulating these cells
with receptor activator of NF-κB ligand (RANKL) induced a rapid and significant increase in …
