Innate immune signaling in the myelodysplastic syndromes

DT Starczynowski, A Karsan - Hematology/Oncology Clinics, 2010 - hemonc.theclinics.com
The innate immune system is an evolutionarily conserved defense mechanism against
pathogens. 1 Unlike the adaptive immune response, the innate immune system does not
recognize every foreign pathogen, but instead recognizes related components shared by
many microbes, referred to as ''pathogen-associated molecular patterns.''Coordinated
activation of the innate immune system is achieved by key sentinel cells and a complex
sequence of events, including engagement of pathogen-associated molecular patterns …