In vivo evidence of deep brain stimulation-induced dopaminergic modulation in Tourette's syndrome
J Kuhn, H Janouschek, M Raptis… - Biological …, 2012 - biologicalpsychiatryjournal.com
To the Editor: Due to its large effect size, deep brain stimulation (DBS) is progressively
considered in the treatment of medicationresistant Tourette's syndrome (TS)(1).
Nevertheless, the underlying beneficial mechanisms of DBS in TS are still a matter of debate
(2, 3). Treatment strategies (D2-receptor antagonists) as well as previous research results
point to a dysfunction of basal gangliarelated circuits and hyperactive dopaminergic
innervations (4–8). It might thus be hypothesized that DBS acts via modulation of dopamine …
considered in the treatment of medicationresistant Tourette's syndrome (TS)(1).
Nevertheless, the underlying beneficial mechanisms of DBS in TS are still a matter of debate
(2, 3). Treatment strategies (D2-receptor antagonists) as well as previous research results
point to a dysfunction of basal gangliarelated circuits and hyperactive dopaminergic
innervations (4–8). It might thus be hypothesized that DBS acts via modulation of dopamine …
